A promising new non-opioid pain reliever (analgesic) has been discovered, with potentially fewer side effects than other powerful pain relievers. A team of researchers led by scientists from the University of Warwick’s School of Life Sciences analyzed a compound known as BnOCPA (benzyloxy-cyclopentyladenosine), which was found to be a potent and selective non-addictive analgesic in test model systems. BnOCPA also has a unique mode of action, which could provide a new pathway for the development of analgesic drugs....

Basel: “So gefährlich, du kannst nicht alleine zur Schule gehen” – schreibt das Kind (12) an die Polizei Autos ziehen von der Route 50 über den Bürgersteig zur Tankstelle und versperren teilweise den Weg, weil der Platz nicht ausreicht. Nach dem Brief eines betroffenen Kindes an die Polizei tut sich nun etwas. 1/5 Hot Spot: Autos vor der Tankstelle blockieren den Bürgersteig auf der Hauptstraße. Eltern wollen nicht, dass ihre Kinder auf dem Schulweg alleine dort vorbeikommen....

President Biden on Monday attacked members of the GOP “MAGA” caucus in a Labor Day speech in Wisconsin, as the president hardens his sides against Republicans ahead of the midterms. “I want to be very clear up front, not every Republican is a MAGA Republican. Not every Republican embraces this extreme ideology,” Biden said at a rally in Milwaukee. “I know because I’ve been able to work with mainstream Republicans throughout my career....

The 40-year-old singer told 15-year-old Jaden: “You were like my other family. You secretly enjoyed looking at me like there was something wrong with me before asking, “Do you want me to get better so I can keep giving your dad 40 euros a month?” Spears then opened up about becoming an atheist because of what she experienced during her Conservative tenure, which ended last year, and how she was treated by her children and family, stating that her father Jamie, 70, “I have to he is in prison for the rest of his life....

Around 7 a.m., reporters spotted uniformed officers and police vehicles outside the home of Clark County Public Administrator Robert Telles, who had been the focus of German’s recent reporting. Authorities had also taped a section around Telles’ home. Shortly before 9 a.m., police said they were serving search warrants in the 7200 block of Bronze Circle, where the killing occurred. “No further information will be released at this time,” police said in a statement....

Construction at the Come By Chance refinery has been halted for a week following a fire last Friday that injured eight workers. In a statement released Monday night, Braya Renewable Fuels says construction at the facility has been halted until at least September 12 while an investigation into the incident is ongoing. They say the resumption of work will be reassessed by them and Occupational Health and Safety next week and are starting a plan to safely return to construction activities while the stop work order is in place....

The euro has sunk below $0.99 – a new 20-year low – after Russia’s disruption of gas supplies through its main pipeline to Europe fueled fears of a deepening energy crisis across the region. The euro has become increasingly correlated with natural gas prices in recent months, with the former falling when prices for the energy source rose. Europe is trying to wean itself off Russian supplies and build up stocks ahead of the cold winter months, but investors estimate the hit to its economy will be huge....

Aber obwohl die Regierung über neue Coronavirus-Daten von hoher politischer Bedeutung verfügt, will sie die Bürger und Abgeordneten vorerst nicht darüber informieren! Lesen Sie mit BILDplus, was es mit den Daten auf sich hat und warum die Veröffentlichung die Entscheidung über neue Maßnahmen deutlich erschweren könnte!

Déterminés, les Palois ont poussé les Verts à 10. Cette fois, Evan a été victime d’une faute dans le coin gauche de la surface de réparation. Et une nouvelle fois, Saivet montrera toute sa classe en trompant pour la deuxième fois Mathieu Dreyer, qui venait de remplacer Green (2-1, 79e). On pensait les Palois sains et saufs mais, après un centre innocent, Xavier Kouassi énerve Wadji dans la surface. L’arbitre M....

Kwarteng writes in the Financial Times that while there will need to be “some fiscal easing”, the new government would act in a “fiscally responsible manner”. Tras allies admitted that the Treasury’s fiscal framework would be revised once the latest figures were assessed, “given the severity of the economic shocks we are facing”. Kwarteng would assess the key fiscal rule that debt must decline as a share of national income in the third year of the forecast period to make sure it still works for the economy, they said....

13h35 : Journées d’intégration scolaire, alors déguisez-vous….. 13h35 : C’est un parapluie ! 13h35 : Ça sent l’EVJF 😉 13h35 : En attendant, les recherches se poursuivent dans les commentaires de cette fameuse photo d’une épée en pleine tempête à Montpellier. Personnellement, je suis plus convaincu par l’hypothèse du jour de l’adhésion que par celle du parapluie (on y voit clairement une poignée d’épée). (MAXPPP) 13h07 : Excellente question, merci de l’avoir posée....

Le Merlu bouffe le Lyon. S’ils finissaient toujours par s’en sortir malgré un niveau moyen depuis le début de la saison, les Lyonnais ont cette fois été punis de leurs lacunes par de séduisants Lorientais ce mercredi à l’occasion de la deuxième journée de Ligue 1. La rencontre démarre à toute allure, alors que Ouattara fait danser la défense lyonnaise. Le numéro s’arrête net lorsque Thiago Mendes sèche le Burkinabé à l’entrée de la surface....

But allies say they have been very surprised not to see her linked to senior posts. The Deputy Prime Minister has the job of facing Angela Rayner in the Commons, including at PMQs if the Prime Minister is absent. Ms Truss is expected to hand over ministerial roles to other former leadership rivals. Nadhim Zahawi, who is currently at the Treasury, will take over the cabinet office as Chancellor of the Duchy of Lancaster....

GlaxoSmithKline GmbH & Co. KG München (ots) – Zwei Drittel der über 60-Jährigen befürchten Krankheit und nachlassende körperliche und geistige Leistungsfähigkeit im Alter – 67 % der Senioren haben Angst vor chronischen Schmerzen – Nur etwa ein Drittel der Menschen über 60 wissen, dass das Alter eine mögliche Ursache für Gürtelrose ist Man sagt, mit Geld kann man viel kaufen – aber Geld ist nicht alles. Eine aktuelle repräsentative Umfrage1 mit dem Meinungsforschungsinstitut Appinio zeigt, dass 93 % der über 60-Jährigen Gesundheit im Alter wichtig ist....

Initially, he was expected to miss a game or two. Explaining the decision, coach Robert Saleh said Wilson won’t play until Week 4 “at the earliest.” The Jets face the Pittsburgh Steelers on the road that week. That means the Jets will open the season with Joe Flacco at quarterback, starting Sunday against the Baltimore Ravens — the team that drafted him in 2008 — at MetLife Stadium. 2 Related “We’re going to make sure the mind and body are 100 percent and make sure we do right by him,” Saleh said of Wilson, the No....

Photos posted online show the SUV on a curb at the intersection with front-end damage and a Saanich police vehicle nearby with damage to the driver’s side front wheel. Saanich Police say Blanshard Street (South) at Ravine Way is closed due to the incident. Traffic is being diverted onto Pat Bay Highway and McKenzie Avenue. Staff Seargent Andy Stuart with Saanich Police tells CHEK News the road is expected to be closed for two to three hours....

The benchmark S&P 500 fell 0.7%, while the Dow Jones Industrial Average fell by the same margin, or about 230 points. The tech-heavy Nasdaq Composite led losses, falling more than 1 percent. The moves come after three consecutive weeks of losses for the major averages. “The market will enter the first full week of September looking to break a three-week losing streak as investors continued to digest the Fed’s ‘we won’t be swayed’ message to fight inflation,” Chris Larkin, managing director of trading of Morgan Stanley....